Coniine hydrochloride( —— )

Catalog No. M23697 CAS No. 15991-59-0

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Product Name

Coniine hydrochloride
Note

Research use only, not for human use.
Brief Description

Coniine hydrochloride, a polyketide-derived alkaloid, is poisonous to humans and animals.
Description

Coniine hydrochloride, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inhibition of the nervous system.
In Vitro

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In Vivo

Animal Model:15-20 g, Swiss-Webster male mice Dosage:0.05 mg-0.2 mg Administration:I.v.Result:Clinical signs was almost immediate after injection, beginning with piloerection, tailflicking, and rapidly progressing to intention tremors, clonic convulsions, muscular weakness, lateral recumbency, and death; shows acute toxicity with an LD50 value of 7.7 mg/kg.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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1.Hannu H , Heiko R . The killer of Socrates: Coniine and Related Alkaloids in the Plant Kingdom[J]. Molecules, 2017, 22(11):1962.

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